VDM Marango, J: The Multiple Myeloma SET Domain (MMSET) Protein

The t(4;14) translocation, present in ca. 20% of cases of Multiple Myeloma, results in the dysregulation of two potential oncogenes, MMSET and FGFR3, via juxtaposition to regulatory elements of the IgH locus. The presence of t(4;14) and overexpression of transcripts from the MMSET locus are adverse prognostic factors in Multiple Myeloma irrespective of FGFR3 expression, implicating MMSET in disease pathogenesis. MMSET is a biologically active transcriptional effector that could mediate a series of repressive changes by acting as a methyltransferase enzyme in chromatin remodeling and as a complex adaptor in the recruitment of repressor species.